Biotin-Responsive Basal Ganglia disease

a) Discuss some signs and symptoms of biotin deficiency. b) Are the certain drugs that can deplete this vitamin?

Case report you posted of acute quadriplegia in an 10 year old that had presumed Biotin deficiency and found to have basal ganglia lesions. I found an analysis of 10 patients with Biotin-Responsive Basal Ganglia disease in a 2012 report if anyone wants more info (1). Although basal ganglia is grey matter, there are reports of Biotin supplementation positively impacting Multiple Sclerosis, primarily a white matter disease (2). So one of the signs of Biotin deficiency seem to include neuro-inflammatory effects. 

1/Tabarki, B., Al-Shafi, S., Al-Shahwan, S., Azmat, Z., Al-Hashem, A., Al-Adwani, N., Biary, N., Al-Zawahmah, M., Khan, S., Zuccoli, G., 2013. Biotin-responsive basal ganglia disease revisited: Clinical, radiologic, and genetic findings. Neurology 80, 261–267. https://doi.org/10.1212/WNL.0b013e31827deb4c (Links to an external site.)Links to an external site.

2/Sedel, F., Papeix, C., Bellanger, A., Touitou, V., Lebrun-Frenay, C., Galanaud, D., Gout, O., Lyon-Caen, O., Tourbah, A., 2015. High doses of biotin in chronic progressive multiple sclerosis: A pilot study. Multiple Sclerosis and Related Disorders 4, 159–169. https://doi.org/10.1016/j.msard.2015.01.005 (Links to an external site.)Links to an external site.