Dietary methionine paradoxical effects

Folate's and B12's role in converting Homo cysteine to Methionine. There are several paradoxical issues nutritionists should be aware of. Just a reminder of the reaction we are discussing from our text:

Besides adequate folate and B12 status, wouldn't we think dietary methionine would lower homocysteine? Paradoxically, this is not the case - methionine restriction results in higher homocysteine levels AND increases lifespan in animal models tested! Important to recall that Homocysteine may be the fireman at the fire so to speak in that its elevation may be a marker for a pathological condition not caused by it. 

Source: 

Ables GP et al. Dietary Methionine Restriction in Mice Elicits an Adaptive Cardiovascular Response to Hyperhomocysteinemia
Sci Rep. 2015; 5: 8886.