What is MTHFR C677T SNP and A1298C SNP and what are the ramifications of this?

What is MTHFR C677T SNP and A1298C SNP and what are the ramifications of this?

Hi Charity - thanks for your post and the research showing how to treat these SNPs. You note that supplementing with vitamin B6 as well as B12 and Folate led to lowered homocysteine levels in those with MTHFR SNP. Here is the folate interconversion chart from our book and note that item 5 is where this MTHFR variation is located:

Coenzymes for this reaction include NADP & Vitamin B2 (FAD). I looked for some research and found that indeed Riboflavin supplements assist in lowering Homocysteine in those with MTHFR SNP. Niacin supplementation would seem to work as well although in a brief search I could not find a reference. 

Source:

1/García-Minguillán, et al. Riboflavin status modifies the effects of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) polymorphisms on homocysteine. Genes Nutr. 2014 Nov;9(6):435. doi: 10.1007/s12263-014-0435-1. Epub 2014 Oct 17.

2/Methylenetetrahydrofolate Reductase. Austin (TX): Landes Bioscience; 2000-2013. 
https://www.ncbi.nlm.nih.gov/books/NBK6145/.