Friday, January 25, 2019

Phosphorous Review

Phosphorous Review

DIGESTION AND ABSORPTION

Organic food forms are digested

  • Hydrolyzed to inorganic phosphate by phosphatases
  • Exception: phospholipids in micelles
  • Exception: digestion-resistant phytic acid

Absorption typically by passive diffusion
  • Active transport available for when intake is low
    • Stimulated by vit D
  • Absorption inhibitors
    • Phytic acid
    • Excessive Mg Al Ca
TRANSPORT, STORAGE, EXCRETION

Ph in the blood
- Phospholipids delivered by chylomicrons
- Inorganic and other organic forms absorbed by facilitated diffusion
Cellular uptake passive
- largest amounts in bone and muscle
Excreted in urine
- influenced by diet, vit D, hormones, acid-base balance

FUNCTIONS and MECHANISMS

Bone mineralization
- PTH, calcitriol, calcitonin influence body Ph balance
- PTH impact of kidney is OPPOSITE Ca - Ph is excreted!



Nucleotide / nucleoside phosphatases
- structural roles
- energy storage and transfer
- intracellular second messenger

Phosphorylation in metabolism
- enzyme activation / deactivation
- vitamin activation

Phospholipids
- membrane structure and function

Acid-Base balance
- Ph main intracellular buffer

Oxygen availability
- 2,3 DPG mediates O2 release from Hg

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